It is advisable to take tinidazole with food to minimize the incidence of epigastric discomfort and other gastrointestinal side-effects. Food does not affect the oral bioavailability of tinidazole. Alcoholic beverages should be avoided when taking tinidazole and for 3 days afterwards.
Bacterial vaginosis
The recommended dose in non-pregnant females is a 1 g oral dose once daily for 5 days taken with food or a 2 g oral dose once daily for 2 days taken with food. The use of tinidazole in pregnant patients has not been studied for bacterial vaginosis.
| 2 g/2-day dosing4 x 500 mg tablets once daily for 2 days, taken with food | 1 g/5-day dosing2 x 500 mg tablets once daily for 5 days, taken with food |
|---|---|
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| Table 1 | |
Trichomoniasis
The recommended dose in both females and males is a single 2 g oral dose taken with food. Since trichomoniasis is a sexually transmitted disease, sexual partners should be treated with the same dose and at the same time.
Giardiasis
The recommended dose in adults is a single 2 g dose taken with food. In pediatric patients older than three years of age, the recommended dose is a single dose of 50 mg/kg (up to 2 g) with food.
Amebiasis
Intestinal
The recommended dose in adults is a 2 g dose per day for 3 days taken with food. In pediatric patients older than three years of age, the recommended dose is 50 mg/kg/day (up to 2 g per day) for 3 days with food.
Amebic liver abscess
The recommended dose in adults is a 2 g dose per day for 3-5 days taken with food. In pediatric patients older than three years of age, the recommended dose is 50 mg/kg/day (up to 2 g per day) for 3-5 days with food. There are limited pediatric data on durations of therapy exceeding 3 days, although a small number of children were treated for 5 days without additional reported adverse reactions. Children should be closely monitored when treatment durations exceed 3 days.
| Indication | Adults | Children > 3 Years of Age |
|---|---|---|
| Trichomoniasis | 2 g single dose* | n/a |
| Giardiasis | 2 g single dose | 50 mg/kg single dose (up to 2 g) |
| Intestinal Amebiasis | 2 g QD × 3 days |
50 mg/kg QD × 3 days (up to 2 g/day) |
| Amebic Liver Abscess | 2 g QD × 3-5 days |
50 mg/kg QD × 3-5 days (up to 2 g/day) |
|
* Treat sexual partners with the same dose and at the same time. Please see full Prescribing Information. |
Table 2 | |
Only Tindamax® is approved to treat both bacterial vaginosis and trichomoniasis (TV).
Clinical Insight
Oral vs vaginal cream therapy: Patient preference for oral dosing is demonstrated to be 84%. More»
Beyond BV
Tindamax® may be prescribed for other infections including:
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